Drug Trials
Challenges for Alzheimer’s and Other Urgent Needs

Summary

DRUG TRIALS: Challenges for Alzheimer’s and Other Urgent Needs
Presented in Partnership with HHMI Tangled Bank Studios
         and
In Collaboration with STAT

In Association with NOVA

This Forum explored the challenges and complexities of drug trials, and how they impact disease treatment and prevention  — particularly for conditions that currently have little or no therapeutic options. As a case study, the panel discussed Alzheimer’s and several drugs in development for that disease, but also addressed broader concerns related to the pharmaceutical testing pipeline for unmet medical needs as a whole. This event was presented in partnership with HHMI Tangled Bank Studios, in collaboration with STAT, and in association with NOVA.

You can watch the NOVA film “Can Alzheimer’s Be Stopped?” online.

Brief Video Highlight

Part of: .

Presented in partnership with HHMI Tangled Bank Studios, in collaboration with STAT, and in association with NOVA

Background Articles

Image Credit: Tangled Bank Studios/Jellyfish Pictures

  • The Forum Moderator

    Welcome everyone. Our event has begun.

  • Louise Chang

    Will this be recorded?

    • The Forum Moderator

      Yes, we will post the full video on demand on this site next week. The video also will be on YouTube.

  • The Forum Moderator

    This event is presented in partnership with HHMI Tangled Bank Studios, in collaboration with STAT, and in association with NOVA.

  • The Forum Moderator

    NOVA premiered a film “Can Alzheimer’s Be Stopped?” this week, and you can watch the entire film online at http://www.pbs.org/wgbh/nova/body/alzheimers-be-stopped.html. We’ll be showing 2 short clips from that film during today’s event.

  • The Forum Moderator

    The paper to which Dr. Kesselheim is in: Nature Reviews Drug Discovery 14, 815–816 (2015). http://www.nature.com/nrd/journal/v14/n12/full/nrd4793.html

  • The Forum Moderator

    This clip is from the NOVA film, Can Alzheimer’s Be Stopped?

  • The Forum Moderator

    Dr. Sperling is PI of the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study, aka the A4 study. More info about that trial is here: http://a4study.org/about/

  • The Forum Moderator

    Dr. Tenaerts is executive director of the Clinical Trials Transformation Initiative, which was co-founded by Duke and FDA. More about that initiative: http://www.ctti-clinicaltrials.org/

  • The Forum Moderator

    Dr. Goldstein’s lab researches why men and women face different risks for disorders of the brain. More about her lab is here: http://cnl-sd.bwh.harvard.edu/

  • The Forum Moderator

    We will have a Q&A with our panelists towards the end of this discussion. Do you have a question for the panelists? Post it here. Or email to theforum@hsph.harvard.edu

  • The Forum Moderator

    The NIH offers a website called ClinicalTrials.gov that lists info about more than 200,000 trials at https://clinicaltrials.gov/ct2/home

  • The Forum Moderator

    Quick reminder that you can post questions for the panelists here or email them to theforum@hsph.harvard.edu

  • The Forum Moderator
  • The Forum Moderator

    Our Q&A is about to begin. Email questions to theforum@hsph.harvard.edu

  • The Forum Moderator

    We will post this entire video on this event next week. We also will post on YouTube and iTunesU. The audio will go on SoundCloud and iTunesU.

  • The Forum Moderator

    A searchable transcript of the event also will be posted on this site.

  • The Forum Moderator

    We will wrap up soon and want to thank HHMI Tangled Bank Studios, STAT and NOVA.

  • The Forum Moderator

    Join us again next week:

    HEALTH CARE INEQUALITIES IN AMERICA: The Need for Continuing Reform
    Presented in Collaboration with The Robert Wood Johnson Foundation and NPR
    Wednesday, April 20, 2016
    12:30-1:30pm ET
    Live webcast: https://theforum.sph.harvard.edu/

  • The Forum Moderator

    Thank you all for joining us today!