• The Forum Moderator

    Hello everyone! We’ll be starting in about 10 minutes.

  • The Forum Moderator

    Have questions or comments for our panelists? Post them here.

  • Arizona Yoga

    Hello from Phoenix…

  • Marcus Wagstaff

    When some people use marijuana recreationally, they can and do cause injury to themselves and others. How does legalizing marijuana help make our society safer?

    • Lori Anders

      how does keeping alcohol or tobacco legal help keep our society safer? important to use actual harm/injury data when making these arguments

      • Marcus Wagstaff

        You make a good point – both alcohol and tobacco use/abuse cause great harm to society. Let’s not add to our society’s troubles by legalizing another harmful substance, in this care marijuana.

  • The Forum Moderator

    Hello Arizona Yoga and Marcus Wagstaff! And hello to all our viewers.

  • Marcus Wagstaff

    What’s become of Marinol, a prescription medication form of marijuana, which confers the same benefits of marijuana without the illegality?

  • The Forum Moderator

    Jim Doyle, who is speaking, is a senior fellow at Harvard School of Public Health this fall.

  • The Forum Moderator

    Thanks Marcus. I’ve passed along your questions. I wasn’t familiar with Marinol.

  • The Forum Moderator

    This clip is courtesy of Reuters and shows a marijuana production facility in Colorado.

  • The Forum Moderator

    Colorado is one of two states in the U.S. that has legalized recreational use of marijuana.

  • Lori Anders

    As a parent of 3- my hope/goal is that my children will wait until adulthood to use alcohol or marijuana and understand the risks- and to never use tobacco. If/when they do, it will be much safer if they have a regulated product which will make clear the amount of active ingredient.

  • The Forum Moderator

    Alaska, Oregon and the District of Columbia have the question about legalizing recreational use on the ballots this November

  • The Forum Moderator

    Dr. Evins, who is speaking, contributed an opinion piece to the New York Times about marijuana legalization http://www.nytimes.com/roomfordebate/2013/05/22/how-can-marijuana-be-sold-safely/marijuana-is-a-risky-habit-we-shouldnt-encourage

  • The Forum Moderator

    Dr. Grant directs Center for Medicinal Cannabis Research http://www.cmcr.ucsd.edu/

  • Jo

    Why are the effects on young adults and children so often used as a basis of argument of those opposing legalization, when legalized usage is always restricted to adults? Surely many regulated and, or controlled substance have well known adverse effects in children, which is why they aren’t sold or prescribed to them. Should we make these illegal simply on this basis too?

    • massvocals

      The effect of all legal drugs are the same on children fact 1 that why prohibitionist use it , because children are not grown other studies have shown issue , there uses which is not said become abuse of power by well is by punishment afterwards given to there act , like being thrown out of school or employment or jailed or worst

  • The Forum Moderator

    The center is unusual in that there are few research centers in US with focus on medicinal cannabis

  • MarAli

    I am currently taking chemo and would simply like to say that I was quite amazed at how marijuana eases many of the discomforts from chemo.

  • Todd Johnson

    Minnesota’s Medical Cannabis law is unique in its approach to drug delivery. Only liquid or pill form is legal.

    • massvocals

      lab THC is all that is foolish its liberty issue sir cannabis is freedom form a police state
      all your state is doing is controlling the public right for there own phama

  • The Forum Moderator

    Thanks Jo for your question. I’ll pass it along. And thanks MarAli for posting your observation. Glad you are able to receive comfort!

  • sh

    Does marijuana use have positive cognitive effects, separate from the executive function?

  • The Forum Moderator

    Thanks Todd. Curious about the reasoning behind offering those two forms specifically. Was there concern about controlling access?

  • JonesLa

    Can you post the reference for the article that Jim Doyle was discussing?

  • Lori Anders

    Wondering about views on the current prescription drug abuse problem for adolescents since it is currently above alcohol and marijuana abuse. Any acute or long term studies on cognitive functioning or gateway-addiction studies done for prescription drugs?

  • sh

    How do we turn the clock back on marketing of tobacco to kids? That is, can these be treated similarly?

  • The Forum Moderator

    Hi JonesLa, if I can’t find it by the time we end, I’ll email it to you and post it here, too, for others to see.

  • JonesLa

    Sorry, I meant Jeffrey Miron’s article. Thanks!

  • JonesLa

    How about the decrease in opioid overdoses in states with states with medical marijuana or other legalized marijuana laws?

  • The Forum Moderator

    Got it. Thanks. I’ll find out.

  • Zinzi Bailey

    What about some evidence re: teen drug use?
    Do Medical Marijuana Laws Increase Marijuana Use? Replication Study and Extension
    Sam Harper, Strumpf, Kaufman

    Annals of Epidemiology 2012;22:207-12.

    RESULTS: We replicated previously published results showing higher marijuana use in states with medical marijuana laws. Difference-in-differences estimates suggested that passing medical marijuana laws decreased past-month use among adolescents by 0.53 percentage points (95% CI: 0.03-1.02) and had no discernible effect on the perceived riskiness of monthly use. Models incorporating measurement error in the state estimates of marijuana use yielded little evidence that passing medical marijuana laws affects marijuana use.

    CONCLUSIONS: Accounting for confounding by unmeasured state characteristics and measurement error had an important effect on estimates of the impact of medical marijuana laws on marijuana use. We find limited evidence of causal effects of medical marijuana laws on measures of reported marijuana use.

  • sh

    How about regulating it to the point where there is no profit motive or commercial competition? If there is no profit motive, then it might not be worth expanding the market beyond the default.

    • Dave_K

      One of the problems with legalization and regulation is that initially it has to compete with a very large black market for drugs run by the Mexican drug cartels. Many of the states in the West have legalized and regulated with the intention of harming this black market. This market also makes other drugs available to those who seek marijuana, including kids. If the regulated market prices marijuana too high by excessive taxes the black market will continue to thrive. Local business entering the market to produce marijuana expect to make money. Without that expectation there would not be a local market to compete with the black market. The point to look for is one that allows local businesses to make some money while undercutting the highly inflated black market profits that comprise the market prior to regulation. There is some evidence that this approach is having an impact on the Mexican drug cartels. The Washington Post ran an article recently suggesting that the prices paid to farmers in Sinaloa, Mexico had fallen from $100 per kilo five years ago to around $25 per kilo recently. Many farmers there are reporting that they are no longer willing to grow marijuana. The cartels are estimated to make 60% of their profits from marijuana sales. Unfortunately, the cartels have adapted by growing opium poppies to boost their production of heroin. They are market heroin to those who addicted to prescription opiates as a cheaper alternative.

  • Zinzi Bailey

    I would also like a link to Jeffrey Miron’s article, if possible.

  • Marcus Wagstaff

    Anything with addiction potential needs to be very carefully handled – because of the consequent injuries often caused as a result of those trying to satisfy that craving.

    • Dave_K

      “Because cannabinoid receptors, unlike opioid receptors, are not located in the brainstem areas controlling respiration, lethal overdoses from Cannabis and cannabinoids do not occur. However, cannabinoid receptors are present in other tissues throughout the body, not just in the central nervous system, and adverse effects include tachycardia, hypotension, conjunctival injection, bronchodilation, muscle relaxation, and decreased gastrointestinal motility.

      Although cannabinoids are considered by some to be addictive drugs, their addictive potential is considerably lower than that of other prescribed agents or substances of abuse. The brain develops a tolerance to cannabinoids.

      Withdrawal symptoms such as irritability, insomnia with sleep electroencephalogram disturbance, restlessness, hot flashes, and, rarely, nausea and cramping have been observed. However, these symptoms appear to be mild compared with withdrawal symptoms associated with opiates or benzodiazepines, and the symptoms usually dissipate after a few days.

      Unlike other commonly used drugs, cannabinoids are stored in adipose tissue and excreted at a low rate (half-life 1–3 days), so even abrupt cessation of cannabinoid intake is not associated with rapid declines in plasma concentrations that would precipitate severe or abrupt withdrawal symptoms or drug cravings.

      Since Cannabis smoke contains many of the same components as tobacco smoke, there are valid concerns about the adverse pulmonary effects of inhaled Cannabis. A longitudinal study in a noncancer population evaluated repeated measurements of pulmonary function over 20 years in 5,115 men and women whose smoking histories were known. While tobacco exposure was associated with decreased pulmonary function, the investigators concluded that occasional and low-cumulative Cannabis use was not associated with adverse effects on pulmonary function (forced expiratory volume in the first second of expiration [FEV1] and forced vital capacity [FVC]).”

      National Cancer Institute at the National Institute of Health:

      http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/AllPages/Print

  • The Forum Moderator

    Hi Zinzi, sure. I’ll send it to you.

  • The Forum Moderator

    Thanks, too, sh and Marcus for your comments.

  • CJ

    Can you discuss the difference between the use of pure marijuana versus drugs with the active ingredients of marijuana for medical use? Thank you.

  • Hello, thank you for this opportunity. I am from Social Model Recovery Systems, Inc., in California, and the office I am under works in prevention, marijuana being one.
    Rafael Cabrera
    Community Centered Emergency Room Project

  • Vanessa Gonzales

    i thought there was a age restriction in obtaining legal marijuana.. How are adolescents getting a hold of these?

    • The Forum Moderator

      Hi Vanessa, yes, you are correct.

  • The Forum Moderator

    Great Rafel. So glad you can join us today. Hope the discussion is useful to you.

  • Marcus Wagstaff

    What’s become of Marinol, a prescription medication form of marijuana, which confers the same benefits of marijuana without the illegality?

    • ronald souza

      Marinol doesn’t work for pain… the plant works best when its in its Pure State

    • Dave_K

      Patients typically prefer to continue their use of smoked marijuana rather than to use Marinol. Marinol takes a long time to become effective and patients often reported that they would either experience not much of an effect or that they would feel overmedicated. Smoked marijuana has the advantage of working rapidly and those who smoked reported that they could better control the amount in their systems than they had been able to with an oral dose of Marinol. Marinol did not confer the same benefits as smoked marijuana.

  • ronald souza

    With all the Research and knowing Marijuana Helps/Cures and Pills KILL! Whats the hold up on the Legalization on the World level? Marijuana is the Key to saving Lives and the economy

  • Andrew Trowbridge

    Like cigarettes and alcohol, it would make sense that there needs to be a minimum age to purchase any product containing any amount of marijuana, thc, etc.. Is a minimum age and ID validation policy being considered?

  • Steven Flores

    I joined this informative session just now, thanks for presenting this.

  • Lori Anders

    Marijuana & ADHD & Anxiety- positive mental effects? Seems many adolescents are drawn to self medicate, and some pediatricians have found greater success using marijuana than with Ritalin. Seems we are overly concerned about test results- cognitive higher functioning- leading to rx drug abuse in high performing schools.

  • The Forum Moderator

    These are great questions and comments. We’ll try to get to as many as we can.

  • The Forum Moderator

    Todd Johnson — our audience member is now citing the Minnesota example as you did. Interesting model.

  • JonesLa

    Are other states funding marijuana legalization research centers like CA?

  • The Forum Moderator

    I am not aware of any but am wondering if any of our viewers may know?

    • homie

      of course bish wheat

  • The Forum Moderator

    We will be wrapping up soon. We’re so glad that you were able to join us today.

  • The Forum Moderator

    Sorry we were unable to get to all of these great questions!

  • The Forum Moderator

    We will post the video on demand here in full in the next 2 days and post it on YouTube and iTunesU.