William Mair was a panelist for the Forum’s discussion on Living Longer and Happier Lives.
William Mair directs a laboratory at Harvard T.H. Chan School of Public Health that studies the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.